Eur. Phys. J. Appl. Phys.
Volume 39, Number 2, August 2007NUMELEC 2006
|Page(s)||171 - 174|
|Section||Characterization of Materials: Imaging, Microscopy and Spectroscopy|
|Published online||10 May 2007|
Optimization of a probe for the spectroscopic electrical characterization of biological tissues
Ampère, CNRS, UMR 5005, École Centrale de Lyon, 69134 Ecully, France
2 Ampère, CNRS, UMR 5005, Université Lyon 1, 69622 Villeurbanne, France
3 Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brasil
Corresponding author: email@example.com
Revised: 15 March 2007
Accepted: 22 March 2007
Published online: 10 May 2007
The spectroscopic electrical characterization of biological tissues between 10 Hz and 10 MHz is generally based on four-electrode impedance measurement. An array of four aligned needle-electrodes is commonly used for the probe. The electrode/sample interface impedances and the parasitic capacitances of the system induce measurement inaccuracies respectively in the low and high parts of the studied frequency range. These inaccuracies cannot be removed by any usual calibration method but can be minimized by modifying the geometry of the probe. Using a 3D finite element model of the probe coupled with a deterministic optimization algorithm, it is shown that the configuration of the electrodes should be different at 10 Hz and 10 MHz to improve the performances of the measurement system.
PACS: 87.16.Dg – Membranes, bilayers, and vesicles / 87.80.-y – Biological techniques and instrumentation; biomedical engineering
© EDP Sciences, 2007
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