Eur. Phys. J. Appl. Phys.
Volume 30, Number 1, April 2005
|Page(s)||65 - 73|
|Section||Physics of Biological Systems|
|Published online||28 January 2005|
Influence of the medium rigidity on the growth of multicellular tumor spheroids
INFM - Dept. of Physics, Polytechnic of Torino, C.so Duca degli Abruzzi
24, 10129 Torino, Italy
2 LIMA Bioinformatics Center, Bioindustry Park of Canavese, Via Ribes 5, 10010 Colleretto Giacosa, TO, Italy
Revised: 16 August 2004
Accepted: 7 October 2004
Published online: 28 January 2005
The physical interactions of a growing tumor mass with the host tissue (boundary conditions) play an important role in the dynamics of the tumor and their comprehension is essential for designing new therapeutic tools and methods against cancer. Starting from experiments and biological information, we focus here on the analysis of the effects of the coupling between the host's mechanical properties and some relevant cellular processes involved in the growth of multicellular tumor spheroids. The physical-mathematical model proposed here to describe such a coupling and the respective numerical simulations, after validation through a quantitative comparison with experimental data, will be applied to support biological hypotheses previously formulated and to propose new themes of investigation.
PACS: 87.17.Aa – Cellular structure and processes: theory and modeling; computer simulation / 87.18.Bb – Multicellular phenomena: computer simulation / 87.18.Hf – Multicellular phenomena: spatiotemporal pattern formation in cellular populations
© EDP Sciences, 2005
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